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Barbiturate is a group of sleep enhancer and tranquilizer drugs that are made from barbituric acid.
Chemical composition
As described above barbiturates are derived from barbituric acid. So they are available in the form of any salt of barbituric acid.
Mode of action
Barbiturates act by suppressing central nervous system. They relax the muscles of central nervous system by minimizing the activity of nerves. Our nervous system has a very important chemical that acts as neurotransmitter and it is called gamma amino butyric acid (GABA). The nerves of the central nervous system use this chemical neurotransmitter to be in touch with each other. The barbiturate suppresses this gamma amino butyric acid and in turn nerves are relaxed.
Pentobarbital is a short acting barbiturate. We can say it is a dangerous drug because when used in high doses, it leads to death.
Chemical formulation:
O O
HN NH
O
Pentobarbital is also available in the form of the salt of barbiturates. The process of synthesis of pentobarbital is very much like that of amobarbital. A little difference is that the alkylation of α-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane and produces pentobarbital.
Mechanism of action: Pentobarbital go through first-pass metabolism inside liver and most probably in small and large intestines.
Drug-Drug interaction: When pentobarbital is administered with other drugs such as benzodiazepines, ethanol, opioids, antihistamines, and any other sedative-hypnotic drugs, its action is enhanced. More sedative and hypnotic effect is observed.
Pharmacokinetics: Oral bioavailability of pentobarbital is 70-90% and rectal bioavailability is 90%. Its protein binding is 20-45% and elimination half-life is 15-48hours.
It is also used as anesthetic agent for treatments of animals.
It is also used in Reye’s syndrome to minimize intracranial pressure.
It is also used in euthanasia of animals as well as humans.
This drug was used for criminals for putting them to death.
Numbutal was the brand name of pentobarbital by Abbott Pharmaceuticals. It was available in yellow capsules in 50gm and 100gm. But this drug is discontinued from 1990 because of some suspicious deaths due to over dosage of Numbutal.
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Barbiturates are tranquilizing agents derived from barbituric acid. Pentobarbital is a short acting barbiturate. Its high dose can lead to death. In old times it was used for criminals. It is medically used as anesthetic agent in humans as well as animals.
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Barbiturates act by suppressing central nervous system. They relax the muscles of central nervous system by minimizing the activity of nerves. Our nervous system has a very important chemical that acts as neurotransmitter and it is called gamma amino butyric acid (GABA). The nerves of the central nervous system use this chemical neurotransmitter to be in touch with each other. The barbiturate suppresses this gamma amino butyric acid and in turn nerves are relaxed.
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Pentobarbital is a short acting barbiturate. We can say it is a dangerous drug because when used in high doses, it leads to death.
Chemical formulation:
O O
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Pentobarbital is also available in the form of the salt of barbiturates. The process of synthesis of pentobarbital is very much like that of amobarbital. A little difference is that the alkylation of α-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane and produces pentobarbital.
Mechanism of action: Pentobarbital go through first-pass metabolism inside liver and most probably in small and large intestines.
Drug-Drug interaction: When pentobarbital is administered with other drugs such as benzodiazepines, ethanol, opioids, antihistamines, and any other sedative-hypnotic drugs, its action is enhanced. More sedative and hypnotic effect is observed.
Pharmacokinetics: Oral bioavailability of pentobarbital is 70-90% and rectal bioavailability is 90%. Its protein binding is 20-45% and elimination half-life is 15-48hours.
Uses of pentobarbital:
Pentobarbital is used for sedation and hypnosis.
It is used in the treatment of sleeplessness.
It is also used as anesthetic agent for treatments of animals.
It is also used in Reye’s syndrome to minimize intracranial pressure.
It is also used in euthanasia of animals as well as humans.
This drug was used for criminals for putting them to death.
Numbutal was the brand name of pentobarbital by Abbott Pharmaceuticals. It was available in yellow capsules in 50gm and 100gm. But this drug is discontinued from 1990 because of some suspicious deaths due to over dosage of Numbutal.
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CONCLUSION
Barbiturates are tranquilizing agents derived from barbituric acid. Pentobarbital is a short acting barbiturate. Its high dose can lead to death. In old times it was used for criminals. It is medically used as anesthetic agent in humans as well as animals.
REFERENCES
https://en.wikipedia.org/wiki/Pentobarbital
https://www.medicinenet.com/barbiturates-oral/article.htm#what_are_barbiturates
https://www.google.com/search?q=what+are+barbiturates&oq=what+are+barbiturates&aqs=chrome.0.69i59j0l7.5035j0j15&sourceid=chrome&ie=UTF-8
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I was diagnosed with an anxiety disorder about 6 years ago. I have always had a hard time going out in public because of it. I talked to my doctor and he recommended medical cannabis. I decided to look into it and I found cbdflowerusa.com. This company has a lot of good reviews and their customers seem to be pleased. I went ahead and purchased some and now I could never go back. It helps out. I would recommend talking to your doctor to find all of your options. I have been using medical cannabis for 3 years and I have improved so much. If you have any questions, feel free to ask!
If you are anything like me, then you might have severe anxiety and depression. There are not a lot of solutions and options for these types of disorders. It took me 3 years to find something that works for me. After doing some research, I found the website https://cbdflowerusa.com/. This company has a nice selection of products that can help with disorders you may have. I found them from an article about overcoming anxiety. I decided to purchase some medical cannabis to see what all the hype was about. It works well. I highly recommend it to anybody looking for a solution; however, it may not suit you best. I recommend doing some research as I did. It may take a while, but you will eventually find what you need. If you have any questions, feel free to ask!
Herbal medicine are more likely be the choice of many now a days specially prescription drugs are not only over the top when it come to price but I also kills your liver along the way. Had a lot of experience with medical cannabis since it's working for me. I learn a lot from this website https://blimburnseeds.com/grandaddy-purple
What i can't understand is if cannabis is considered a medicine... which obviously it is... then why and how are there arbitrary rules that dictate that sometimes in some countries marijuana is considered a medicine, and at other times is not... it seems a little bit ridiculous for me.
As an example... vitamin c is considered medicinal because it wards of colds and flus... although we are smart enough to understand that this medicinal benefit stands true at all times... then how is it that the medicinal benefits of marijuana fluctuate so wildly around the world?
Isn't something that is medicinal simply medicinal? I haven't fully addressed that as a separate blog post on my website, although have started an interesting thread to help push the global cannabis globalization movement forward... and you may view that here - http://jaehkoeb.org/free-the-weed-rules-of-the-game/
Let me know what your thoughts are :) After all, we do have cannabis receptors within our brain and other parts of the body as if we are literally an extension of the plant or the other way around... I guess it is a symbiotic relationship that we need to explore a little more.
Alternative medicine are more accepted now a days due to it's promising results unlike pharmaceutical medicine, alternative medicine don't give negative effect such as kidney and liver problems when it comes to long term use. As for my alternative medicine usage, I use medical marijuana. Different strain has a variety of uses and effect depending on your needs. Like thishttps://www.gyo.green/dutch-passion-glueberry-og-auto-dps-gog-fa.html. This strain has a very potent effect on chronic pains like back pain and joint pain and a lot more.